Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran.

Letter by Moll regarding article, "Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran".

Intracerebral haemorrhage associated with antithrombotic treatment: translational insights from experimental studies.

Little is known about the pathophysiology of intracerebral haemorrhage that occurs during anticoagulant treatment. In observational studies, investigators have reported larger haematoma volumes and worse functional outcome in these patients than in those with intracerebral haemorrhage and a normal coagulation status. The need to prevent extensive haematoma enlargement by rapid reversal of the a...

Hemostasis in Intracranial Hemorrhage

Spontaneous non-traumatic intracerebral hemorrhage (ICH) is associated with high morbidity and mortality throughout the world with no proven effective treatment. Majority of hematoma expansion occur within 4 h after symptom onset and is associated with early deterioration and poor clinical outcome. There is a vital role of ultra-early hemostatic therapy in ICH to limit hematoma expansion. Patie...

Activated prothrombin complex in the management of direct thrombin inhibitor-associated intracerebral haemorrhage.

A 78 year-old man developed sudden-onset aphasia and right hemiparesis 14 days after hospitalisation for severe cellulitis, for which he was receiving meropenem and clindamycin. His medical history included a porcine aortic valve replacement and atrial fibrillation treated with dabigatran (a direct thrombin inhibitor, DTI) 150mg twice daily. His weight was 79kg, body mass index 25mg/m, and esti...

Conservative Management of Dabigatran Overdose: Case Report and Review of Literature

Background: Direct thrombin inhibitors and factor Xa inhibitors are gaining popularity as alternatives to warfarin for patients requiring anticoagulation. Toxicity due to these medications is difficult to manage because overdose experience is very limited and there is no clear guidance on when or whether to use antidote in this setting. Case Presentation: A 50-year-old man with normal renal fu...